Cognitive Training Modulates Brain Hypersynchrony in a Population at Risk for Alzheimer’s Disease
| Autor: | David López-Sanz, Fernando Maestú, María Luisa Delgado-Losada, Ramón López-Higes, Alberto Marcos Dolado, Ricardo Bruña, Mercedes Montenegro-Peña, Pedro Montejo Carrasco, Isabel Suárez-Méndez |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
education.field_of_study
business.industry General Neuroscience Population Brain Disease General Medicine Neuropsychological Tests Magnetic Resonance Imaging Cognitive training Psychiatry and Mental health Clinical Psychology Cognition Text mining Alzheimer Disease Risk Factors Humans Medicine Cognitive Dysfunction Geriatrics and Gerontology business education Clinical psychology |
| Zdroj: | Journal of Alzheimer's Disease. 86:1185-1199 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-215406 |
| Popis: | BackgroundRecent neuroimaging studies in humans and animal models of Alzheimer’s disease (AD) demonstrated brain hyper-synchrony under amyloid burden, which is being identified as a proxy for conversion to dementia. The potential of non-pharmacological interventions to reverse this neurophysiological phenomenon in the early stages of the disease is still an open question. MethodBrain synchrony modulation by cognitive training (CogTr) was examined in a cohort of healthy controls (HC, n = 41, 22 trained) and individuals with subjective cognitive decline (SCD, n = 49, 24 trained). Magnetoencephalographic (MEG) activity and comprehensive neuropsychological scores were acquired before and after completion of a ten-week CogTr program aimed at improving cognitive function and daily living performance. Functional connectivity (FC) analyses were carried out using the phase-locking value. A mixed-effects ANOVA with factors stage (pre-intervention or post-intervention), CogTr (trained or non-trained), and cognitive status (HC or SCD) was used to estimate significant FC changes across MEG recordings.ResultsAlpha-band FC increases were observed for the whole sample (both trained and non-trained), but the effect was different in each group. For the trained group (both HC and SCD), we report a reduction in the FC increase within temporo-parietal and temporo-occipital connections. This effect was particularly manifest in trained participants with SCD, for whom the reduction in the FC increase also correlated with enhanced cognitive performance in different neuropsychological domains (memory, language, and executive function).Conclusions CogTr programs could mitigate the increase in FC observed in preclinical AD, promoting brain synchrony normalization in groups at increased risk for developing the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|