Typical CT findings of COVID-19 pneumonia in patients presenting with repetitive negative RT-PCR

Autor: Giovanni Fontanella, Elio Bignardi, Carlo Brogna, Barbara Brogna, Lanfranco Musto, Emerico Maria Mazza, Antonia Megliola, Martino Alberigo, M Grappone, Petronilla Salvatore
Rok vydání: 2021
Předmět:
medicine.medical_specialty
ARDS
CLIA
chemiluminescent immunoassay
NP/OP
nasopharyngeal and oropharyngeal
Case Report
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
030218 nuclear medicine & medical imaging
03 medical and health sciences
Chest CT
0302 clinical medicine
Internal medicine
ARDS
Acute respiratory distress syndrome
medicine
Radiology
Nuclear Medicine and imaging
RDT
rapid diagnostic test
Respiratory system
COVID-19
coronavirus disease 2019
Lung
SARS-CoV-2
business.industry
Serological platforms
False Negative Reactions
COVID-19
Gold standard (test)
medicine.disease
CT
computed tomography
CRP
C-reactive-protein
Pneumonia
Diarrhea
GGOs
ground-glass opacities
Real-time polymerase chain reaction
medicine.anatomical_structure
Repeated negative RT-PCR
030220 oncology & carcinogenesis
medicine.symptom
business
RT-PCR
polymerase chain reaction
Zdroj: Radiography (London, England : 1995)
ISSN: 1078-8174
DOI: 10.1016/j.radi.2020.09.012
Popis: Multiple polymerase chain reaction (RT-PCR) is considered the gold standard diagnostic investigation for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19). However, false negative multiple polymerase chain reaction (RT-PCR) results can be diagnostically challenging. We report three patients with history of fever and different clinical signs. During the height of the pandemic in Italy (March to May 2020), these patients underwent chest computed tomography (CT) scans that showed lung alterations typical of COVID-19 with multiple negative RT-PCR tests and positive serology for SARS-CoV-2. Two of the three patients showed residual pneumonia on CT after the onset of the first clinical signs. One patient presented with diarrhoea without respiratory symptoms. These cases suggest that in the COVID-19 pandemic period, to provide an earlier specific treatment in patients with positive serology, a chest CT scan can be useful in those presenting with a fever or a history of fever associated with persistent mild respiratory symptoms or with abdominal complaints despite repeated negative RT-PCR results.
Databáze: OpenAIRE
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