Nucleotide sequence of the gene encoding the serotype-specific glycoprotein of UK bovine rotavirus
| Autor: | Ian H. Holmes, T.C. Elleman, Michael L. Dyall-Smith, P.A. Hoyne, Ahmed A. Azad |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Rotavirus
Genes Viral Base pair Biology medicine.disease_cause Viral Proteins Complementary DNA Genetics medicine Animals Amino Acid Sequence Cloning Molecular Peptide sequence Gene Sequence (medicine) Glycoproteins chemistry.chemical_classification Base Sequence Nucleic acid sequence DNA DNA Restriction Enzymes Molecular biology chemistry Genes DNA Viral Cattle Glycoprotein Plasmids |
| Zdroj: | Nucleic acids research. 11(14) |
| ISSN: | 0305-1048 |
| Popis: | The nucleotide sequence of the gene which encodes the major outer-shell glycoprotein of UK bovine rotavirus has been determined. The dsRNA genome segment encoding this protein was converted into ds cDNA and cloned into pBR322 for sequence studies. The gene is 1062 base pairs in length and contains a single, long, open reading-frame capable of coding for a protein of 326 amino-acids. This would leave 5' and 3' non-coding regions of 48 and 36 nucleotides in the mRNA. The predicted amino-acid sequence contains three possible glycosylation sites of the type Asn-X-Ser Thr, and an extremely hydrophobic N-terminal region. This sequence is discussed in the light of the known properties and functions of the protein. |
| Databáze: | OpenAIRE |
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