Possible Participation of Histamine H3-Receptors in the Regulation of Anaphylactic Histamine Release from Isolated Rat Peritoneal Mast Cells
| Autor: | Kohji Ogawa, Katsuya Ohata, Hideki Yamamura, Shigekatsu Kohno, Takeshi Nabe, Shintaro Nakao |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Mepyramine Histamine Antagonists In Vitro Techniques Histamine Release Histamine Agonists chemistry.chemical_compound Piperidines Dimaprit Internal medicine medicine Animals Receptors Histamine H3 p-Methoxy-N-methylphenethylamine Mast Cells Histamine H4 receptor Rats Wistar Anaphylaxis Peritoneal Cavity Chromatography High Pressure Liquid Pyrilamine Pharmacology Thioperamide Dose-Response Relationship Drug L-Lactate Dehydrogenase Methylhistamines Compound 48/80 Mast cell Rats Endocrinology medicine.anatomical_structure chemistry Anticonvulsants Peritoneum Histamine H3 receptor Cimetidine Histamine medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 66:173-180 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.66.173 |
| Popis: | Anaphylactic histamine release from isolated rat peritoneal mast cells was concentration-dependently blocked by a 5-min treatment with exogenous histamine at 0.9 and 9 microM and enhanced by a 20- to 30-min treatment with thioperamide (H3-antagonist) at 3 microM with significance, but little affected by mepyramine (H1-antagonist) and cimetidine (H2-antagonist) at the cell concentration of 10(6) mast cells/ml. At a low concentration of mast cells (10(4) mast cells/ml), (R)-alpha-methylhistamine (alpha-MH), an H3-agonist, at 0.9-90 microM also inhibited the release in a concentration-dependent fashion. Thioperamide, but neither mepyramine nor cimetidine, significantly restored the decreased release by alpha-MH. However, the complete restoration by thioperamide could not be achieved because the drug itself slightly but concentration-dependently inhibited anaphylactic histamine release. On the other hand, not only betahistine and dimaprit but also alpha-MH did not suppress histamine release from the mast cells induced by compound 48/80. In rat plasma, considerable levels of histamine were detected. From these results, it is strongly suggested that histamine H3-like receptors are largely responsible for the negative feedback regulation of the anaphylactic histamine release from rat peritoneal mast cells. |
| Databáze: | OpenAIRE |
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