New possibilities for egg white lysozyme: heat-denatured lysozyme partially inactivates select foot-and-mouth disease virus strains
| Autor: | Kazuyuki Inoue, Makoto Yamakawa, Katsuhiko Fukai, Akira Takeuchi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Protein Denaturation Hot Temperature Science 030106 microbiology Fmd virus medicine.disease_cause Article 03 medical and health sciences chemistry.chemical_compound Egg White Virology medicine Infectivity Multidisciplinary biology Chemistry biology.organism_classification Antivirals Hepatitis a virus 030104 developmental biology Foot-and-Mouth Disease Virus Norovirus Medicine RNA Viral Virus Inactivation Muramidase Foot-and-mouth disease virus Lysozyme Bacteria Egg white Disinfectants |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-5 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Foot-and-mouth disease (FMD) is one of the most contagious diseases of cloven-hoofed animals. Disinfectants are used to inactivate FMD virus (FMDV) in Japan. Reports that heat-denatured lysozyme inactivates bacteria as well as viruses, such as norovirus and hepatitis A virus, led us to determine its effects on FMDV. We show here that heat-denatured lysozyme partially inhibited the infectivity of FMDV O/JPN/2010-1/14C but of FMDVs A/TAI/46-1/2015 and Asia1/Shamir (ISR/3/89). Further, heat-denatured lysozyme variably reduced RNA loads of FMDVs O/JPN/2010-1/14C, O/MOG/2/Ca/BU/2017, O/Taiwan/1997, Asia1/Shamir (ISR/3/89), Asia1/TUR/49/2011, SAT1/KEN/117/2009, SAT2/SAU/6/2000 and SAT3/ZIM/3/83 but could not those of O/JPN/2000, A/TAI/46-1/2015, A22/IRQ/24/64, A15/TAI/1/60 and C/PHI/7/84. These findings indicate that heat-denatured lysozyme may serve as a new disinfectant against FMDV. |
| Databáze: | OpenAIRE |
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