A splicing mutation accounts for the lack of p53 gene expression in a CML blast crisis cell line: a novel mechanism of p53 gene inactivation
| Autor: | HG Ahuja, M. Bar-Eli, A Foti, Martin J. Cline |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Genetics
Mutation Base Sequence Point mutation Molecular Sequence Data Intron Gene Expression Hematology Biology Blotting Northern medicine.disease_cause Polymerase Chain Reaction Cell Line Blotting Southern Cell culture Leukemia Myelogenous Chronic BCR-ABL Positive Gene expression RNA splicing medicine Humans Coding region Blast Crisis Gene |
| Zdroj: | British Journal of Haematology. 76:143-145 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1990.tb07849.x |
| Popis: | Alterations of the p53 anti-oncogene have recently been found to occur frequently in the blast crisis of chronic myelocytic leukaemia. The p53 gene may be altered by gross structural alterations or by point mutations in the coding sequence. We now report a novel mechanism of gene inactivation in a blast crisis cell line where a mutation in a splice donor site at the 5' end of the fifth intron of the gene interrupts RNA processing and gene expression. |
| Databáze: | OpenAIRE |
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