Do the smoking intensity and duration, the years since quitting, the methodological quality and the year of publication of the studies affect the results of the meta-analysis on cigarette smoking and Acute Myeloid Leukemia (AML) in adults?
| Autor: | Vittoria Colamesta, Silvia D'Aguanno, Sara Bruffa, Claudio Cartoni, Giuseppe La Torre, Massimo Breccia |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Databases Factual cigarette acute myeloid leukemia Affect (psychology) tobacco smoking Cohort Studies 03 medical and health sciences 0302 clinical medicine Cigarette smoking Risk Factors Internal medicine Medicine Humans 030212 general & internal medicine Methodological quality business.industry Myeloid leukemia Hematology Fixed effects model Former Smoker Leukemia Myeloid Acute Oncology 030220 oncology & carcinogenesis Meta-analysis Cohort Physical therapy Periodicals as Topic business |
| Popis: | Background The aim was to perform a systematic review and meta-analysis on the relationship between tobacco smoking and the onset of acute myeloid leukemia (AML) in adults. Methods PubMed and Scopus databases were systematically searched. In the meta-analysis, random or fixed effects models were used according to the presence of heterogeneity. Study quality was assessed using the Newcastle-Ottawa Scale. Results Twenty-seven articles were included. Case-control and cohort meta-analyses show that current, ever and former smokers have a significant increased risk to develop AML compared to never smokers [current: OR = 1.36 (1.11–1.66) and RR = 1.52 (1.10–2.14); ever: OR = 1.25 (1.14–1.38) and RR = 1.45 (1.10–1.90); former: OR = 1.21 (1.03–1.41) and RR = 1.45 (1.08–1.94)]. Moreover, increasing smoking intensity and duration is associated with an increase of the risk, OR shift from 1.14 (1–20 pack/years) to 2.36 (>40 pack/years). Discussion and conclusion Smoking may have a significant role in AML onset in a multistep pathogenesis. |
| Databáze: | OpenAIRE |
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