Early-life manipulation of cortisol and its receptor alters stress axis programming and social competence

Autor: Maria Reyes-Contreras, Gaétan Glauser, Diana J. Rennison, Barbara Taborsky
Rok vydání: 2019
Předmět:
Fish Proteins
Hypothalamo-Hypophyseal System
medicine.medical_specialty
Coping (psychology)
Hydrocortisone
Physiological
mifepristone
Neolamprologus pulcher
Biology
Stress
Medical and Health Sciences
General Biochemistry
Genetics and Molecular Biology
Glucocorticoid
Hormone Antagonists
Receptors
Glucocorticoid
Mineralocorticoid receptor
Glucocorticoid receptor
Stress
Physiological
Internal medicine
Receptors
medicine
Animals
Social Behavior
Evolutionary Biology
Cichlids
Articles
Mifepristone
Biological Sciences
biology.organism_classification
early-life effects
Endocrinology
Hypothalamus
developmental plasticity
570 Life sciences
biology
590 Animals (Zoology)
Developmental plasticity
Social competence
General Agricultural and Biological Sciences
corticosteroid receptor
hormones
hormone substitutes
and hormone antagonists
HPA/HPI axis
medicine.drug
Zdroj: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol 374, iss 1770
ISSN: 1471-2970
0962-8436
DOI: 10.1098/rstb.2018.0119
Popis: In many vertebrate species, early social experience generates long-term effects on later life social behaviour. These effects are accompanied by persistent modifications in the expression of genes implicated in the stress axis. It is unknown, however, whether stress axis programming can affect the development of social competence, and if so, by which mechanism(s). Here, we used pharmacological manipulations to persistently reprogramme the hypothalamic–pituitary–interrenal axis of juvenile cooperatively breeding cichlids, Neolamprologus pulcher. During the first two months of life, juveniles were repeatedly treated with cortisol, mifepristone or control treatments. Three months after the last manipulation, we tested for treatment effects on (i) social competence, (ii) the expression of genes coding for corticotropin-releasing factor ( crf ), glucocorticoid receptor ( gr1 ) and mineralocorticoid receptor ( mr ) in the telencephalon and hypothalamus and (iii) cortisol levels. Social competence in a social challenge was reduced in cortisol-treated juveniles, which is in accordance with previous work applying early-life manipulations using different social experiences. During early life, both cortisol and mifepristone treatments induced a persistent downregulation of crf and upregulation of mr in the telencephalon. We suggest that these persistent changes in stress gene expression may represent an effective physiological mechanism for coping with stress. This article is part of the theme issue ‘Developing differences: early-life effects and evolutionary medicine’.
Databáze: OpenAIRE
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