Embryo selection criteria based on morphology VERSUS the expression of a biochemical marker (sHLA-G) and a graduated embryo score: prediction of pregnancy outcome
| Autor: | Geoffrey Sher, Levent Keskintepe, Ellen Snowden, Thinus F. Kruger, Dirk Kotze, Polly Hansen |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Pregnancy Rate Biology Miscarriage HLA Antigens Pregnancy Genetics medicine Humans Embryo Implantation Sperm Injections Intracytoplasmic Genetics (clinical) Selection (genetic algorithm) Gynecology HLA-G Antigens Histocompatibility Antigens Class I Pregnancy Outcome Obstetrics and Gynecology Embryo General Medicine medicine.disease Embryo Transfer Embryo Mammalian Embryo transfer Abortion Spontaneous Pregnancy rate Assisted Reproduction Reproductive Medicine Female Biomarkers Developmental Biology |
| Zdroj: | Journal of assisted reproduction and genetics. 27(6) |
| ISSN: | 1573-7330 |
| Popis: | To compare pregnancy and implantation rates when embryos are selected based on a single Day 3 (D 3) morphology score vs. a GES score plus sHLA-G expression.A prospective randomized study (n = 214) undergoing fresh ICSI cycles. Embryos were selected for transfer based on either Day 3 morphology score (Group A) or GES-scoring plus sHLA-G expression (Group B).Clinical [35/107 (33%) vs. 52/107 (49%)] and ongoing pregnancy [20/107 (19%) vs. 52/107 (49%)] rates were significantly different between Group A and Group B (p0.05). Implantation rates were not significantly different between Group A [52/353 (15%)] and Group B [73/417 (18%)] (p0.05). The number of pregnancies lost during the first trimester was nearly 12 times higher in Group A [25/52 (48%)].The miscarriage rate was significantly lower in Group B than Group A and the pregnancy results were superior when embryos were selected based on GES plus sHLA-G expression. |
| Databáze: | OpenAIRE |
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