Increased serum uric acid level predicts poor prognosis in mildly severe chronic heart failure with reduced ejection fraction. An analysis from the MECKI score research group
| Autor: | Angela Beatrice Scardovi, Michele Correale, Carlo Lombardi, Roberto Badagliacca, Francesco Doni, Gianfranco Sinagra, Giuseppe Limongelli, Federica Re, Piergiuseppe Agostoni, Elisabetta Salvioni, Francesco Clemenza, Stefania Paolillo, Ugo Corrà, Rocco La Gioia, Massimo Francesco Piepoli, Michele Emdin, Rosa Raimondo, Alice Bonomi, Mariantonietta Cicoira |
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| Přispěvatelé: | Piepoli, M. F., Salvioni, E., Corra, U., Doni, F., Bonomi, A., La Gioia, R., Limongelli, G., Paolillo, S., Sinagra, G., Scardovi, A. B., Raimondo, R., Emdin, M., Re, F., Cicoira, M., Correale, M., Badagliacca, R., Clemenza, F., Lombardi, C., Agostoni, P. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Uric acid
prognosis medicine.medical_specialty Poor prognosis Renal function Heart failure 030204 cardiovascular system & hematology Nyha class 03 medical and health sciences Ventricular Dysfunction Left heart failure prognosis uric acid 0302 clinical medicine Kidney function male left Internal medicine middle aged Internal Medicine medicine 030212 general & internal medicine Hyperuricemia Hemoglobin humans Cardiopulmonary exercise test Kidney Ejection fraction business.industry Increased serum uric acid ventricular dysfunction medicine.disease aged medicine.anatomical_structure stroke volume Cardiology business cardiopulmonary exercise test hemoglobin kidney function uric acid prognosis ventricular dysfunction left |
| Popis: | Background: Hyperuricemia prognostic impact on clinical outcomes in chronic heart failure (HF) patients has been investigated with inconclusive results. Objectives: Aim of the study was to evaluate the prognostic impact of serum uric acid (SUA) on long-term clinical outcomes in HF. Methods: An analysis of MECKI (Metabolic Exercise Cardiac Kidney Index) database, with median follow-up of 3.4 years. Results: Relation between SUA and all-cause/ cardiovascular (CV) deaths have been analysed in 4,577 patients (3,688 males, age 62.7 ± 12.9 years), with reduced ejection fraction HF (35 ± 11%), peakVO2 1151 ± 440 ml/min; NYHA class I-II (72.6%), III-IV (27.4%). SUA was associated with increased total and CV mortality (HR 1.120 and HR 1.128, respectively p < 0.0001), also after adjustment for peakVO2, VE/VCO2 slope, diuretic use and MECKI score. SUA was significantly associated with CV mortality only in NYHA class I-II (HR 1.17, p < 0.0001) while there was no association in class III-IV (HR 1.03, p = NS). No prognostic added values of SUA with respect to the MECKI score was observed at the ROC analysis. Conclusions: SUA is confirmed to be associated with increased mortality, but in less severe HF only. However SUA did not show additional prognostic power to the MECKI score |
| Databáze: | OpenAIRE |
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