Brazilian Red Propolis Accelerates Gastric Healing and Reduces Gastric Submucosal Layer Inflammation in Ultrasound‐Monitored Rats

Autor: Thaise Boeing, Beatriz Monteiro Magalhães de Oliveira, Jennyfer Andrea Aldana‐Mejía, Gari Vidal Ccana‐Ccapatinta, Larissa Venzon, Benhur Judah Cury, Tauani Caroline Santos França, Priscila de Souza, Walter Antônio Roman Junior, Luísa Mota da Silva, Jairo Kenupp Bastos
Rok vydání: 2022
Předmět:
Zdroj: Chemistry & Biodiversity. 20
ISSN: 1612-1880
1612-1872
DOI: 10.1002/cbdv.202200992
Popis: Propolis has been used for the treatment of gastric disturbances in folk medicine, nevertheless, the gastric healing effects of Brazilian red propolis have not been unveiled. This study aimed to assess the gastric healing effect of the hydroalcoholic extract of red propolis (HERP) in the acetic acid-induced ulcer model. Rats under acetic acid-induced-ulcer were treated with HERP (100 mg/kg, p.o.) twice a day for seven days. Histological changes, oxidative stress, and inflammatory parameters were analyzed in the gastric tissue. Moreover, the gastric wall thickness was measured by ultrasound. The in vitro cytotoxicity of HERP and cellular migration of fibroblasts were evaluated. The treatment with HERP promoted gastric healing, reducing gastric wall thickness, macroscopic lesion area, and histopathological damages compared to the vehicle. Moreover, HERP reduced oxidative stress and inflammation in the gastric tissue but did not change mucin or collagen levels. HERP did not show signs of toxicity either in vivo or in vitro. HERP displayed a healing effect in vivo by reducing oxidative stress and inflammation. These data contribute to validating the popular use of this product in the treatment of gastric disorders and advance scientific knowledge in the search for new drugs for the management of gastric ulcers.
Databáze: OpenAIRE
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