The stereoselective disposition of the enantiomers of ibuprofen in blood, blister and synovial fluid
| Autor: | Km M. Williams, F. Lohrer, Mw W. Duncan, Peter Seideman, Ro O. Day, Gg G. Graham |
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| Rok vydání: | 1994 |
| Předmět: |
Ibuprofen
Models Biological Gas Chromatography-Mass Spectrometry Absorption Arthritis Rheumatoid Reaction rate constant Pharmacokinetics Synovial Fluid medicine Humans Synovial fluid Pharmacology (medical) Chromatography High Pressure Liquid Pharmacology Chromatography Chemistry Reproducibility of Results Half-life Stereoisomerism medicine.disease Blood blister Stereoselectivity Enantiomer Extracellular Space Half-Life Protein Binding Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 38:221-227 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1994.tb04345.x |
| Popis: | 1. A sensitive, stereospecific assay using gas chromatography-mass spectrometry (GC/MS) was established to measure the concentrations of the enantiomers of ibuprofen in small volumes (50 microliters) of blister fluid. 2. The concentrations of the enantiomers in blister fluid, assessed in eight patients, were similar to those in synovial fluid, both fluids behaving as peripheral compartments with respect to plasma. 3. The mean rate constants of transfer of R-ibuprofen into (0.14 +/- 0.06 h-1) and out of (0.20 +/- 0.04 h-1) blister fluid were not significantly different from those for synovial fluid (0.19 +/- 0.12 h-1, 0.34 +/- 0.11 h-1, respectively). Similarly, the mean rate constants of transfer of S-ibuprofen into (0.22 +/- 0.07 h-1) and out of (0.27 +/- 0.08 h-1) blister fluid were not significantly different from those for synovial fluid (0.29 +/- 0.10, 0.36 +/- 0.11 h-1). However, the correlations were poor between the transfer constants for each of the enantiomers between plasma, and both blister and synovial fluid (P > 0.2). 4. The complex rate constant of transfer of S-ibuprofen into blister fluid (0.22 +/- 0.07 h-1) was greater than that of R-ibuprofen (0.14 +/- 0.07 h-1), which may be explained by the lesser protein binding of the S-enantiomer.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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