Nasopharyngeal Colonization With Nontypeable Haemophilus Influenzae And Recurrent Otitis Media
| Autor: | Judy Wolf, Deborah Krystofik, Noboru Yamanaka, Linda C. Duffy, Yasuaki Harabuchi, Howard Faden |
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| Rok vydání: | 1994 |
| Předmět: |
Immunoglobulin A
biology business.industry Mucous membrane medicine.disease_cause Haemophilus influenzae Microbiology Infectious Diseases Immune system Otitis medicine.anatomical_structure Immunology medicine biology.protein Immunology and Allergy Colonization medicine.symptom business Breast feeding Respiratory tract |
| Zdroj: | Journal of Infectious Diseases. 170:862-866 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/170.4.862 |
| Popis: | University of Chicago Press, Harabuchi, Y. ; Faden, H. ; Yamanaka, N. ; Duffy, L. ; Wolf, J. ; Krystofik, D. ; Williamsville, T.,Journal of Infectious Diseases, 170(4), 1994, 862-866. publisher The relationship between nasopharyngeal colonization with nontypeable H. influenzae and recurrent otitis media was assessed in 157 children followed prospectively from birth through 12 months of age. Forty-nine (31%) became colonized. Nasopharyngeal secretory IgA (sIgA) reactive with the P6 outer membrane protein was detected in all colonized children. Reduction or elimination of the organism was associated with a better mucosal immune response (560 +/- 864 units/ng/mL of sIgA) than was persistence in the nasopharynx (121 +/- 81; P = .04). Forty colonized children (82%) and 61 noncolonized children (56%) developed otitis media (P = .004); colonized children were four times more likely to be classified as otitis prone (P = .003). The frequency of otitis media episodes was directly related to the frequency of colonization (r = .42, P < .01). These results demonstrate a strong relationship between nasopharyngeal colonization patterns and otitis media. The mucosal immune response may be important in elimination of potential pathogens from the respiratory tract. |
| Databáze: | OpenAIRE |
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