Intraocular penetration of liposomal amphotericin B after intravenous injection in inflamed human eyes
Autor: | Yusuke Manabe, Kazuhiro Murata, Daisuke Takagi, Katsuhiko Kamei, Daisuke Todokoro, Kana Matsumoto, Tomoko Ando, Ayaka Yagasaki, Kunihiko Morita, Yoshiaki Niwa, Noriaki Yamada, Kiyofumi Mochizuki, Shinji Ogura, Hideaki Kawakami |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Antifungal Agents genetic structures 030106 microbiology Keratitis 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine Endophthalmitis Ophthalmology Amphotericin B Cornea medicine Humans Pharmacology (medical) Fungal keratitis 030212 general & internal medicine business.industry Chorioretinitis medicine.disease eye diseases Infectious Diseases medicine.anatomical_structure Injections Intravenous sense organs business Intraocular penetration medicine.drug |
Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 27(9) |
ISSN: | 1437-7780 |
Popis: | Purpose To determine the intraocular penetration of amphotericin B (AMPH-B) after an intravenously injection of liposomal amphotericin B (L-AMB) in inflamed human eyes. Methods Seven eyes of 5 patients with fungal eye diseases (endophthalmitis in 6 eyes and keratitis in 1 eye) were treated with intravenous injections of 100–250 mg/day of L-AMB. Samples of blood, corneal button, aqueous humor, and vitreous humor were collected and assessed for AMPH-B. Results The AMPH-B level in the cornea (604.0 μg/g) of the case with fungal keratitis exceeded the minimum inhibitory concentration. However, the levels in the aqueous and vitreous humors of the cases with fungal endophthalmitis were lower, e.g., 0.02 ± 0.01 μg/ml (0.09% of serum level) in the aqueous humor and 0.05 ± 0.08 μg/ml (0.17% of serum level) in the vitreous humor. Conclusions The AMPH-B levels administered intravenously were very low in the aqueous and vitreous humors. Our findings indicate that intravenous L-AMB can be considered only for patients with mild endogenous fungal endophthalmitis, e.g., isolated chorioretinitis without vitreous extensions. |
Databáze: | OpenAIRE |
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