Frequency of seropositivity against infectious agents amongst pemphigus vulgaris patients: a case-control study onStrongyloides stercoralis,Helicobacter pylori,Toxoplasma gondii,Leishmania major, and Epstein-Barr virus
| Autor: | Ali Akbar Amirzargar, Iman Vasheghani Farahani, Younes Mohammadi, Pardis Hejazi, Mehdi Mohebali, Ali Khamesipour, Amir Hooshang Ehsani, Hossein Mortazavi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Dermatology Iran Immunoglobulin G Virus Strongyloides stercoralis Antigen Seroepidemiologic Studies Animals Humans Medicine Antigens Viral Direct fluorescent antibody Leishmania major Helicobacter pylori biology business.industry Pemphigus vulgaris Middle Aged biology.organism_classification medicine.disease Case-Control Studies Immunology biology.protein Capsid Proteins Female Antibody business Toxoplasma Immunosuppressive Agents Pemphigus |
| Zdroj: | International Journal of Dermatology. 54:e458-e465 |
| ISSN: | 0011-9059 |
| Popis: | Background Environmental and genetic factors may contribute to the pathogenesis of pemphigus vulgaris (PV) as an autoimmune disease. We aimed to determine rates of seropositivity for immunoglobulin G (IgG) antibodies against a number of infectious agents in untreated and treated PV patients and in healthy individuals. Methods Eighty-two newly diagnosed untreated PV patients (34 men and 48 women; mean ± standard deviation [SD] age: 44.18 ± 14.43 years) and 36 previously diagnosed patients under immunosuppressive therapy (16 men and 20 women; mean ± SD age: 38.53 ± 9.96 years) were enrolled in the study. The clinical diagnosis of PV was confirmed by histopathology and direct immunofluorescence findings. As a control group, 131 healthy individuals (68 men and 63 women; mean ± SD age: 42.56 ± 19.69 years) were recruited. In all patients and controls, serum IgG antibodies against Strongyloides stercoralis, Helicobacter pylori, Epstein–Barr virus (EBV) capsid antigen, and Leishmania major were measured using enzyme-linked immunosorbent assays. The indirect immunofluorescence test was used to detect IgG antibodies against Toxoplasma gondii. Results Newly-diagnosed untreated PV patients had significantly higher rates of seropositivity of IgG antibodies against S. stercoralis and H. pylori compared with the control group (69.5% vs. 16.0% [P |
| Databáze: | OpenAIRE |
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