Plasma adrenomedullin in patients with primary aldosteronism
| Autor: | Yuichiro Ishiyama, Johji Kato, Toru Shimokubo, Kenji Kuwasako, Kazuo Kitamura, Shigeru Nakamura, Yoshinari Ichiki, Miho Tanaka, Tanenao Eto, Kenji Kangawa |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Radioimmunoassay Vena Cava Inferior Inferior vena cava Veins Pheochromocytoma Adrenomedullin Primary aldosteronism Internal medicine Adrenal Glands Hyperaldosteronism Blood plasma Internal Medicine medicine Humans business.industry Osmolar Concentration Middle Aged medicine.disease medicine.anatomical_structure Epinephrine Endocrinology medicine.vein Hypertension Female Peptides business Adrenal medulla medicine.drug |
| Zdroj: | American Journal of Hypertension. 8:997-1000 |
| ISSN: | 0895-7061 |
| Popis: | Adrenomedullin (AM) is a novel hypotensive peptide originally isolated from the pheochromocytoma tissue of humans. To examine the pathophysiological role of AM in primary aldosteronism (PA), the plasma concentration of AM in patients with PA was measured with a specific radioimmunoassay and compared to that in age- and sex-matched healthy normotensive subjects. In addition, the concentrations of AM as well as catecholamines in the plasma from both the adrenal vein and the inferior vena cava (IVC) were measured to determine whether or not the circulating AM in these PA patients is supplied from the adrenal medulla, which contains a much higher concentration of AM than any other human tissue does. The plasma concentration of AM in the PA patients (4.57 +/- 0.32 fmol/mL, n = 6) was significantly (P.01) higher than that in the healthy subjects (3.06 +/- 0.20 fmol/mL, n = 12). A significant positive correlation (r = 0.62, P.01) was observed between the mean blood pressure and the plasma AM level. The AM concentration in plasma from the adrenal vein was almost the same level as that from the IVC although the concentrations of both epinephrine and norepinephrine in the adrenal vein were much higher than those in the IVC. Therefore, it seems unlikely that the plasma AM in the PA patients is mainly supplied from the adrenal medulla. Judging from the potent hypotensive activity of AM, the present findings suggest that AM participates in defense mechanisms acting against the elevation of blood pressure in the patients with PA. |
| Databáze: | OpenAIRE |
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