Associations of endogenous sex hormone levels with the prevalence and progression of valvular and thoracic aortic calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)

Autor: Matthew J. Budoff, Oluseye Ogunmoroti, Erin D. Michos, Pamela Ouyang, Isac C. Thomas, Oluwaseun E. Fashanu, Apurva Sharma, Di Zhao
Rok vydání: 2022
Předmět:
Male
Descending thoracic aortic calcification
medicine.medical_specialty
Aging
Clinical Sciences
Disease
Cardiorespiratory Medicine and Haematology
Cardiovascular
Article
symbols.namesake
Sex hormone-binding globulin
Risk Factors
Clinical Research
Internal medicine
Mitral annular calcification
Prevalence
Medicine
Humans
Testosterone
Poisson regression
Endogenous sex hormones
Aetiology
Gonadal Steroid Hormones
Vascular Calcification
Heart Disease - Coronary Heart Disease
biology
business.industry
Incidence (epidemiology)
Prevention
Aortic Valve Stenosis
medicine.disease
Atherosclerosis
Extra coronary calcification
Hormones
Sex hormone binding globulin
Heart Disease
Good Health and Well Being
Cardiovascular System & Hematology
Cohort
biology.protein
Cardiology
symbols
Female
Aortic valve calcification
Cardiology and Cardiovascular Medicine
business
Calcification
2.4 Surveillance and distribution
Zdroj: Atherosclerosis
Popis: Background and aimsSex hormones (SH) may contribute to sex differences in cardiovascular disease (CVD). High free testosterone (T) and low sex hormone binding globulin (SHBG) have been associated with progression of coronary artery calcification in women. We now examined the association of SH with extra-coronary calcification (ECC) prevalence and progression among MESA participants.MethodsWe studied 2,737 postmenopausal women and 3,130 men free of clinical CVD with baseline SH levels. ECC measurements [ascending and descending thoracic aortic calcification (ATAC, DTAC), mitral annular calcification (MAC), aortic valve calcification (AVC)] were obtained by computed tomography at baseline and after 2.4±0.9 years. We used multivariable Poisson regression to evaluate associations with ECC prevalence and incidence (Agatston scores >0) and linear mixed effects models for ECC progression, per 1-SD increment in log(SH) in women and men separately.ResultsThe mean age was 65±9 and 62±10 years for women and men, respectively. In women, greater free T and lower SHBG were associated with MAC incidence in a demographic-adjusted model only. In men, lower free T was associated with MAC prevalence, DTAC incidence and progression, while greater SHBG was associated with MAC prevalence and DTAC progression after further adjusting for CVD risk factors.ConclusionsIn this diverse cohort free of CVD, we found some associations of SH with ECC measures. In particular, free T was inversely associated with prevalent MAC and DTAC progression in men independent of CVD risk factors. SH may influence vascular calcification, but further work is needed to understand clinical implications of these findings.
Databáze: OpenAIRE
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