Peripheral eosinophilia and hypoalbuminemia are associated with a higher biopsy diagnostic yield for eosinophilic gastroenteritis
| Autor: | Erica J. Brenner, Ellen L. Cowherd, Sydney B. Greenberg, S. Ryanne Corder, Evan S. Dellon, Nicole C. Chang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Biopsy Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Metabolic Diseases Internal medicine Eosinophilia Gastroscopy Eosinophilic gastroenteritis Medicine Humans Hypoalbuminemia Child Hepatology medicine.diagnostic_test business.industry Stomach Infant Newborn Infant medicine.disease Enteritis Endoscopy medicine.anatomical_structure 030220 oncology & carcinogenesis Child Preschool Gastritis Cohort Duodenum 030211 gastroenterology & hepatology Female medicine.symptom business |
| Zdroj: | Clin Res Hepatol Gastroenterol |
| ISSN: | 2210-741X |
| Popis: | BACKGROUND: Gastric and duodenal mucosa may appear normal in eosinophilic gastroenteritis (EGE). Adult gastroenterologists typically biopsy only in the setting of mucosal abnormalities or symptoms, while pediatric providers biopsy all patients. The biopsy yield of EGE has not been adequately evaluated. AIMS: To evaluate the biopsy yield of EGE in a pediatric cohort and assess predictors of increased biopsy yield. METHODS: We identified patients age 0–18 who underwent upper endoscopy. We recorded endoscopic findings, pathology, demographics, and clinical and laboratory characteristics. We identified EGE cases (>20 eosinophils per high-power field on stomach and/or duodenum biopsy). We compared characteristics between EGE and non-EGE cases, calculated biopsy diagnostic yield, and performed multivariate analysis for predictors of increased biopsy yield. RESULTS: In 509 patients (55.6% female, mean age 10.3 years, 69.7% white, 58.7% atopic), biopsy diagnostic yield for EGE was 1.2% (6/509) among all subjects, 7.7% (3/39) for those with peripheral eosinophilia (≥500 eos/uL), 9.1% (3/33) for those with hypoalbuminemia ( |
| Databáze: | OpenAIRE |
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