Angiotensin II type 1 and type 2 receptor-induced cell signaling
| Autor: | Masamichi Yano, Hiroshi Akazawa, Chizuru Yabumoto, Yoko Kudo-Sakamoto, Issei Komuro |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Cell signaling Endothelin receptor type A Protein Conformation Biology Receptor Angiotensin Type 2 Receptor Angiotensin Type 1 Internal medicine Drug Discovery medicine Animals Humans Receptor Coagulation factor II receptor Pharmacology Angiotensin II receptor type 1 Angiotensin II Endocrinology Interleukin-21 receptor cardiovascular system Calcium Stress Mechanical Signal transduction hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology Signal Transduction |
| Zdroj: | Current pharmaceutical design. 19(17) |
| ISSN: | 1873-4286 |
| Popis: | The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling. Ang II activates Ang II type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family. Most of the actions of Ang II such as promotion of cellular prolifaration, hypertrophy, and fibrosis are mediated by AT1 receptor. However, in some pathological situations, AT2 receptor shows an increase in tissue expression and functions to antagonize the actions induced by AT1 receptor. Recent studies have advanced our understanding of the molecular mechanisms underlying receptor activation and signal transduction of AT1 and AT2 receptor in the cardiovascular system. |
| Databáze: | OpenAIRE |
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