Overexpression of CD168 is related to poor prognosis in oral squamous cell carcinoma

Autor:	Su‐Wen Zhu, Shuo Wang, Zhi‐Zhong Wu, Qi‐Chao Yang, De‐Run Chen, Shu‐Cheng Wan, Zhi‐Jun Sun
Rok vydání:	2021
Předmět:	Otorhinolaryngology Head and Neck Neoplasms Squamous Cell Carcinoma of Head and Neck Biomarkers Tumor Carcinoma Squamous Cell Humans Mouth Neoplasms Prognosis General Dentistry
Zdroj:	Oral Diseases. 28:364-372
ISSN:	1601-0825 1354-523X
Popis:	Receptor for hyaluronic acid (HA)-mediated motility (RHAMM) is also known as CD168. This study proposed to elucidate the prognostic and clinicopathological significance of CD168 expression in oral squamous cell carcinoma (OSCC).Immune staining of a human tissue microarray and Western blot were used to reveal the expression level of CD168 in OSCC. Correlations between clinicopathological indexes and CD168 expression in OSCC patients were assessed.Increased expression of CD168 was detected in OSCC tissues. High expression of CD168 indicated worse survival of patients (p .05). Furthermore, high expression of CD168 was related to pathological grade in OSCC (p .05). CD168 expression was positively related to programmed death ligand 1 (PD-L1), CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6), B7 homology 4 protein (B7-H4), CD44, CD133, and Slug expression in OSCC.This study revealed the overexpression of CD168 in OSCC and shed light on the prognostic significance of CD168 expression in OSCC patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf49cae9af415df0d35f45d35e03d96c https://doi.org/10.1111/odi.13766 Zobrazit plný text záznamu Plný text