Increased levels of soluble corin in pre-eclampsia and fetal growth restriction
| Autor: | Asuka Kambayashi, Yoshiteru Noda, Takema Kato, Takao Sekiya, Hiroki Kurahashi, Haruki Nishizawa, Hironori Miyamura, Sumire Terasawa, Kazuya Shiogama, Jun Miyazaki, Mayuko Ito, Takuma Fujii |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Placenta 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Syncytiotrophoblast Downregulation and upregulation Atrial natriuretic peptide Pre-Eclampsia Pregnancy Internal medicine medicine Decidua Maternal hypertension Humans reproductive and urinary physiology 030219 obstetrics & reproductive medicine Eclampsia Fetal Growth Retardation business.industry Serine Endopeptidases Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Trophoblasts Endocrinology medicine.anatomical_structure Blood pressure Reproductive Medicine embryonic structures Female business Immunostaining Developmental Biology |
| Zdroj: | Placenta. 48 |
| ISSN: | 1532-3102 |
| Popis: | Atrial natriuretic peptide is biologically activated by the atrial natriuretic peptide-converting enzyme, corin, and has an important role in regulating blood pressure. We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction (FGR) without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension. CORIN mRNA levels were not elevated in placentas from pre-eclampsia or unexplained FGR cases. Likewise, similar signal intensities were found for corin in placental syncytiotrophoblast cells by immunostaining. In contrast, corin signals were higher in maternal decidua cells from pre-eclampsia and unexplained FGR cases. These data suggest that corin may be upregulated in maternal decidua in response to an etiologic pathway that is common to pre-eclampsia and FGR. |
| Databáze: | OpenAIRE |
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