Study of Magnesium Formulations on Intestinal Cells to Influence Myometrium Cell Relaxation
| Autor: | Sara Ruga, Corrado Magnani, Mahitab Farghali, Francesca Uberti, Felice Notte, Antonio Nardone, Vera Morsanuto, Chiarella Bozzo, Claudio Molinari, Rebecca Galla |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Magnesium absorption Biological Availability chemistry.chemical_element lcsh:TX341-641 030209 endocrinology & metabolism Permeability Article Intestinal absorption Nitric oxide Contractility Uterine Contraction 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans magnesium supplementation Magnesium Viability assay Intestinal Mucosa Chelating Agents Nutrition and Dietetics Intestinal permeability Smooth muscle tissue myometrial contractility Myometrium Muscle Smooth medicine.disease magnesium mechanisms 030104 developmental biology medicine.anatomical_structure Intestinal Absorption chemistry PHM1- 41 cells Dietary Supplements Biophysics Female Caco-2 Cells lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Nutrients, Vol 12, Iss 2, p 573 (2020) Volume 12 Issue 2 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12020573 |
| Popis: | Background: Magnesium is involved in a wide variety of physiological processes including direct relaxation of smooth muscle. A magnesium imbalance can be considered the primary cause or consequence of many pathophysiological conditions. The smooth muscle tissue of the uterus, i.e., the myometrium, undergoes numerous physiological changes during life, fundamental for uterine activities, and it receives proven benefits from magnesium supplementation. However, magnesium supplements have poor absorption and bioavailability. Furthermore, no data are available on the direct interaction between intestinal absorption of magnesium and relaxation of the myometrium. Methods: Permeability in human intestinal cells (Caco-2 cells) and direct effects on myometrial cells (PHM1-41 cells) of two different forms of magnesium, i.e., sucrosomial and bisglycinate, were studied in order to verify the magnesium capacity of modulate contractility. Cell viability, reactive oxygen species (ROS) and nitric oxide (NO) production, magnesium concentration, contractility, and pathways involved were analyzed. Results: Data showed a better influence of buffered chelate bisglycinate on intestinal permeability and myometrial relaxation over time with a maximum effect at 3 h and greater availability compared to the sucrosomial form. Conclusions: Magnesium-buffered bisglycinate chelate showed better intestinal absorption and myometrial contraction, indicating a better chance of effectiveness in human applications. |
| Databáze: | OpenAIRE |
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