Complex Systems Biology Approach in Connecting PI3K-Akt and NF-κB Pathways in Prostate Cancer
| Autor: | Eswar Shankar, Meenakshi Shukla, Sanjay Gupta, Sree N. Sreenath, Sanjeev Shukla, Jayant Avva, Michael C. Weis |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Transcription Genetic Systems biology IκB kinase Biology Article NF-κB 03 medical and health sciences chemistry.chemical_compound Phosphatidylinositol 3-Kinases 0302 clinical medicine Cell Line Tumor Humans Computer Simulation Phosphorylation lcsh:QH301-705.5 Protein kinase B Transcription factor PI3K/AKT/mTOR pathway 030304 developmental biology Cell Proliferation 0303 health sciences PI3K/Akt Epidermal Growth Factor Kinase Systems Biology NF-kappa B Prostatic Neoplasms General Medicine 3. Good health Cell biology I-kappa B Kinase Crosstalk (biology) lcsh:Biology (General) chemistry 030220 oncology & carcinogenesis I-kappa B Proteins Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Cells Cells, Vol 8, Iss 3, p 201 (2019) Volume 8 Issue 3 |
| ISSN: | 2073-4409 |
| Popis: | Phosphatidylinositol 3&prime OH kinase (PI3K)-Akt and transcription factor NF-&kappa B are important molecules involved in the regulation of cell proliferation, apoptosis, and oncogenesis. Both PI3K-Akt and Nuclear Factor-kappaB (NF-&kappa B) are involved in the development and progression of prostate cancer, however, the crosstalk and molecules connecting these pathway remains unclear. A multilevel system representation of the PI3K-Akt and NF-&kappa B pathways was constructed to determine which signaling components contribute to adaptive behavior and coordination. In silico experiments conducted using PI3K-Akt and NF-&kappa B, mathematical models were modularized using biological functionality and were validated using a cell culture system. Our analysis demonstrates that a component representing the I&kappa B kinase (IKK) complex can coordinate these two pathways. It is expected that interruption of this molecule could represent a potential therapeutic target for prostate cancer. |
| Databáze: | OpenAIRE |
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