Isoniazid acetylation phenotyping in Saudi Arabs
| Autor: | Saleh A. Bawazir, F Z Al-Faleh, A Y Mayet, A Al-Wazzan, E A Ayoola, Kamal M. Matar |
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| Rok vydání: | 2004 |
| Předmět: |
Oral dose
Adult Male medicine.medical_specialty Adolescent education Antitubercular Agents Saudi Arabia Pharmacology Gastroenterology SLOW ACETYLATOR PHENOTYPE Gene Frequency Acetyltransferases Internal medicine medicine Isoniazid Humans Pharmacology (medical) Allele frequency Antibacterial agent Aged Plasma samples business.industry Acetylation Middle Aged bacterial infections and mycoses eye diseases respiratory tract diseases Phenotype Female business geographic locations medicine.drug |
| Zdroj: | Journal of clinical pharmacy and therapeutics. 29(5) |
| ISSN: | 0269-4727 |
| Popis: | Summary Aims: The present study is designed to investigate the acetylator status in Saudi Arabs. Methods: Isoniazid (INH) acetylation phenotyping was studied in 136 Saudi Arabs in Riyadh, Saudi Arabia, using a single plasma sample taken 3 h post-INH oral dose of 200 mg. Metabolic ratio (MR) of plasma acetyl-INH (Ac-INH) to INH was used to determine the acetylation phenotype. Results: The MR had a bimodal distribution with an antimode of 1·0. The frequency distribution of slow acetylators (MR |
| Databáze: | OpenAIRE |
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