Cellular and humoral response to the fourth BNT162b2 mRNA COVID‐19 vaccine dose in patients with CLL
| Autor: | Ohad Benjamini, Rotem Gershon, Erez Bar‐Haim, Yaniv Lustig, Hila Cohen, Ram Doolman, Meirav Kedmi, Elena Ribakovsky, Abraham Kneller, Tammy Hod, Noam Erez, Itzhak Levy, Galia Rahav, Abraham Avigdor |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Journal of Haematology. 110:99-108 |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/ejh.13878 |
| Popis: | We assessed the humoral and cellular response to the fourth BNT162b2 mRNA COVID-19 vaccine dose in patients with CLL. A total of 67 patients with CLL and 85 age matched controls tested for serologic response and pseudo-neutralization assay. We also tested the functional T-cell response by interferon gamma (IFNγ) to spike protein in 26 patients. Two weeks after the fourth vaccine antibody serologic response was evident in 37 (55.2%) patients with CLL, 20 /22 (91%) of treatment naïve, and 9/32 (28%) patients with ongoing therapy, compared with 100% serologic response in age matched controls. The antibody titer increased by 10-fold in patients with CLL, however, still 88-folds lower than age matched controls. Predictors of better chances of post fourth vaccination serologic response were previous positive serologies after second, third, and pre-fourth vaccination, neutralizing assay, and treatment naïve patients. T-cell response improved from 42.3% before the fourth vaccine to 84.6% 2 weeks afterwards. During the time period of 3 months after the fourth vaccination, 14 patients (21%) developed COVID-19 infection, all recovered uneventfully. Our data demonstrate that fourth SARS-CoV-2 vaccination improves serologic response in patients with CLL to a lesser extent than healthy controls and induces functional T-cell response. |
| Databáze: | OpenAIRE |
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