Evidence of Inflammatory System Involvement in Parkinson’s Disease
| Autor: | Eng-King Tan, Yin Xia Chao, Siew Cheng Wong |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Inflammation
Parkinson's disease General Immunology and Microbiology lcsh:R lcsh:Medicine Parkinson Disease Review Article General Medicine Disease Biology medicine.disease Communicable Diseases Phenotype General Biochemistry Genetics and Molecular Biology Complement system Immune system Immunity Immunology medicine Humans Microglia Inflammation Mediators medicine.symptom Receptor |
| Zdroj: | BioMed Research International, Vol 2014 (2014) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Parkinson’s disease (PD) is a chronic neurodegenerative disease underpinned by both genetic and environmental etiologic factors. Recent findings suggest that inflammation may be a pathogenic factor in the onset and progression of both familial and sporadic PD. Understanding the precise role of inflammatory factors in PD will likely lead to understanding of how the disease arises.In vivoevidence for inflammation in PD includes dysregulated molecular mediators such as cytokines, complement system and its receptors, resident microglial activation, peripheral immune cells invasion, and altered composition and phenotype of peripheral immune cells. The growing awareness of these factors has prompted novel approaches to modulate the immune system, although it remains whether these approaches can be used in humans. Influences of ageing and differential exposure to environmental agents suggest potential host-pathogen specific pathophysiologic factors. There is a clear need for research to further unravel the pathophysiologic role of immunity in PD, with the potential of developing new therapeutic targets for this debilitating condition. |
| Databáze: | OpenAIRE |
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