Mandibular Osteonecrosis Associated with Antacid Therapy (Esomeprazole)
| Autor: | Saverio Cosola, Ugo Covani, Anna Maria Genovesi, Simone Marconcini, Enrica Giammarinaro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class lcsh:Medicine Proton-pump inhibitor Oral Surgical Procedures antacid therapy Bone remodeling Esomeprazole 03 medical and health sciences 0302 clinical medicine Antacid therapy stomatognathic system esomeprazole Internal medicine Internal Medicine medicine In patient business.industry Mandibular osteonecrosis lcsh:R Jaw bone 030206 dentistry Articles medicine.disease stomatognathic diseases osteonecrosis of the jaw 030220 oncology & carcinogenesis proton pump inhibitors business Osteonecrosis of the jaw medicine.drug |
| Zdroj: | European Journal of Case Reports in Internal Medicine European Journal of Case Reports in Internal Medicine (2019) |
| ISSN: | 2284-2594 |
| Popis: | Introduction Osteonecrosis of the jaw has been consistently reported in the literature associated to the high-dose intravenous bisphosphonate therapy. However, osteonecrosis can also occur in patients who have other risk factors. Case description An unusual case of ONJ in a patient being treated with esomeprazole is reported. Discussion The probable association between proton pump inhibitor intake and osteonecrosis of the jaw should alert clinicians. Collaborations between medical and dental doctor and an early diagnosis might prevent or reduce the morbidity resulting from advanced destructive lesions of the jaw bone. Learning points Osteonecrosis of the jaw (ONJ) can occur in patients treated with bisphosphonates and corticosteroids and is associated with oral surgical procedures involving bone.Antacid drugs commonly used to treat gastro-oesophageal reflux could affect bone metabolism although no cases of ONJ in patients using proton pump inhibitors have been reported.Medical and dental practitioners should collaborate to prevent ONJ, identify previously unreported drug interactions, and treat patients in a more comprehensive manner. |
| Databáze: | OpenAIRE |
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