Preliminary study of the safety of acrinol in probe‐based confocal laser endomicroscopy during transurethral resection of bladder tumors

Autor: Yoshio Naya, Natsuki Takaha, Iseei Hayashi, Masaru Mori, Seiki Date, Osamu Ukimura
Rok vydání: 2022
Předmět:
Zdroj: Asian Journal of Endoscopic Surgery. 16:143-146
ISSN: 1758-5910
1758-5902
Popis: We previously reported that probe-based confocal laser endomicroscopy using acrinol can depict cancerous nuclei. The objective of this study was to confirm the safety of acrinol in patients. For all seven patients, '50 ml' of a 0.1% acrinol and '1 ml' of 10% fluorescein in 99 ml of normal saline were introduced into the bladder. The laser probe adhered to the suspicious lesion from the working channel of the cystoscope. The patients underwent mucosal biopsy and transurethral resection after observation. Adverse events were noted during a valuation using common terminology criteria for adverse events version 4.0. Confocal laser endomicroscopy detected the nuclei of cancer cells in all seven patients. No adverse event was observed in any of the seven patients. Confocal laser endomicroscopy using acrinol as a novel dye can help visualize the cancerous nuclei of bladder urothelial carcinoma during cystoscopy without severe adverse events.
Databáze: OpenAIRE
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