Cardiac and peripheral vascular effects of pralidoxime chloride
| Autor: | Vernon S. Bishop, Merrill B. Kardon, George E. Barnes |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Cardiac output medicine.medical_specialty Reserpine Vascular smooth muscle Cardiac Volume Blood Pressure Dogs Heart Rate Internal medicine Heart rate medicine Animals Heart Atria Cardiac Output Phentolamine Pharmacology Pralidoxime Compounds business.industry Pralidoxime chloride Stroke volume Propranolol Blockade Peripheral Blood pressure Anesthesia Cardiology Female Vascular Resistance business |
| Zdroj: | European Journal of Pharmacology. 20:188-194 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(72)90148-3 |
| Popis: | After each administered i.v. dose of 2-PAM (5, 10, 20 and 40 mg/kg body weight) to open chest anesthetized dogs, cardiac output, arterial pressure, stroke volume and stroke work increased while heart rate decreased. Following α-adrenergic blockade, 2-PAM produced changes similar to those of control animals with the exception that heart rate increased at 40 mg/kg. After β-adrenergic blockade, increases in stroke volume, stroke work, total peripheral resistance and arterial pressure occurred with all doses of 2-PAM. Heart rate decreased while cardiac output was maintained or slightly increased. In reserpine-treated animals, arterial pressure, stroke volume, stroke work and total peripheral resistance increased while heart rate decreased. The results of this study suggest that 2-PAM has a direct stimulatory action on the heart and vascular smooth muscle. |
| Databáze: | OpenAIRE |
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