Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders
| Autor: | Ron Ferszt, Liv Bode, Hanns Ludwig, Roman Stoyloff, W E Severus, P Reckwald, Detlef E. Dietrich |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Bipolar Disorder animal diseases viruses Antigen-Antibody Complex Biology Antibodies Viral Virus Serology Cellular and Molecular Neuroscience Immune system Antigen Animals Humans Horses Mononegavirales Borna disease virus Molecular Biology Antigens Viral Aged Aged 80 and over Borna disease Depressive Disorder Mood Disorders virus diseases RNA virus Middle Aged biology.organism_classification Virology Psychiatry and Mental health Borna Disease Immunology biology.protein Female Horse Diseases Antibody |
| Zdroj: | Molecular psychiatry. 6(4) |
| ISSN: | 1359-4184 |
| Popis: | Borna disease virus (BDV), a unique genetically highly conserved RNA virus (Bornaviridae; Mononegavirales), preferentially targets neurons of limbic structures causing behavioral abnormalities in animals. Markers and virus in patients with affective disorders and schizophrenia have raised worldwide interest. A persistent infection was suggestive from follow-up studies, but inconstant detectability weakened a possible linkage.This study for the first time discloses that detection gaps are caused by BDV-specific circulating immune complexes (CIC), and their interplay with free antibodies and plasma antigens (p40/p24). Screening 3000 sera each from human and equine patients over the past 4 years by new enzyme immunoassays (EIAs) revealed that BDV-CICs indicate 10 times higher infection rates (up to 30% in controls, up to 100% in patients) than did previous serology. Persistence of high amounts of CICs and plasma antigens correlates with severity of depression. Even BDV RNA could be detected in plasma samples with strong antigenemia. Our discovery not only explains the course of persistent infection, but offers novel easy-to-use diagnostic tools by which new insights into BDV-related etiopathogenesis of disease and epidemiology are possible. |
| Databáze: | OpenAIRE |
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