Solution-phase combinatorial synthesis using multicomponent Grignard reagents

Autor:	Mikael Bols, Xifu Liang
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Chemistry Magnesium Reagent Halide chemistry.chemical_element Organic chemistry Grignard reagent Combinatorial synthesis Solution phase Alkyl
Zdroj:	Liang, X & Bols, M 2002, ' Solution-Phase Combinatorial Synthesis using Multicomponent Grignard reagents ', Journal of the Chemical Society, Perkin Transactions 1, pp. 503-508 .
ISSN:	1364-5463 1472-7781
Popis:	Mixtures of up to 8 different alkyl Grignard reagents were prepared from the reaction of alkyl halides with magnesium. These multicomponent Grignard reagents were reacted with aldehydes, ketones or esters to produce mixtures of alcohols. Analysis of the product mixtures showed that from the reactions of aldehydes and ketones uniform mixtures of products were formed, while from the reaction with esters uniform libraries were only obtained after slow addition of the Grignard reagent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4210e3ec0bdb24f7df089be95cc249 https://doi.org/10.1039/b109952n Zobrazit plný text záznamu