The expression of MMP-2 and TIMP-2 in patients with colorectal adenocarcinoma invaded to the submucosal and proper muscle layer
| Autor: | Sotaro Sadahiro, Takehiko Kameya, Masaya Mukai, Hideki Ishida, Isao Ito, Nobuhiro Tokunaga, Hiroyasu Makuuchi, K. Ishikawa, Hirotada Iwase, Tomoo Tajima, Tomihiko Kimura, Kazuhiro Ishizu, Toshiyuki Suzuki |
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| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Colorectal cancer Adenocarcinoma Metastasis medicine Humans Neoplasm Invasiveness Tissue Distribution Intestinal Mucosa Tissue Inhibitor of Metalloproteinase-2 Oncogene business.industry Metalloendopeptidases Cancer Muscle Smooth General Medicine medicine.disease Immunohistochemistry Molecular medicine Oncology Gelatinases Lymphatic Metastasis Cancer cell Matrix Metalloproteinase 2 Colorectal Neoplasms business |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.5.2.335 |
| Popis: | The expression of MMP-2 and TIMP-2 was examined immunohistochemically in a total of 87 colorectal cancer patients. The expression of MMP-2 was in cancer cells: 76.5% (sm), 16.7% (pm), in cancer interstitial region: 92.2% (sm), 58.3% (pm), in transitional mucosal cells: 74.3% (sm), 17.1% (pm) and in transitional mucosal interstitial region: 80.0% (sm), 31.4% (pm). The expression of TIMP-2 was in cancer cells: 41.2% (sm), 16.7% (pm), in cancer interstitial region: 82.4% (sm), 69.4% (pm), in transitional mucosal cells: 57.1% (sm), 22.9% (pm) and in transitional mucosal interstitial region: 89.3% (sm), 57.1% (pm). These results suggest that the expression of MMP-2 and TIMP-2 is induced in the sm cancer stage and is closely related to interactions in the cancer interstitial region for invasion and metastasis in patients with colorectal adenocarcinoma. |
| Databáze: | OpenAIRE |
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