Physicochemical Properties and Cellular Responses of Strontium-Doped Gypsum Biomaterials
| Autor: | Hadis Bandegani, Masoud Alizadeh, Amir Pouria, Saeed Hesaraki, Milad Pourbaghi-Masouleh |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
musculoskeletal diseases
inorganic chemicals Gypsum Article Subject Simulated body fluid lcsh:Biotechnology Mineralogy chemistry.chemical_element engineering.material Biochemistry Inorganic Chemistry chemistry.chemical_compound Strontium nitrate lcsh:TP248.13-248.65 lcsh:Inorganic chemistry Solubility Strontium Chemistry Organic Chemistry Microstructure lcsh:QD146-197 Compressive strength Distilled water engineering Nuclear chemistry Research Article |
| Zdroj: | Bioinorganic Chemistry and Applications Bioinorganic Chemistry and Applications, Vol 2012 (2012) |
| ISSN: | 1687-479X 1565-3633 |
| Popis: | This paper describes some physical, structural, and biological properties of gypsum bioceramics doped with various amounts of strontium ions (0.19–2.23 wt%) and compares these properties with those of a pure gypsum as control. Strontium-doped gypsum (gypsum:Sr) was obtained by mixing calcium sulfate hemihydrate powder and solutions of strontium nitrate followed by washing the specimens with distilled water to remove residual salts. Gypsum was the only phase found in the composition of both pure and gypsum:Sr, meanwhile a shift into lower diffraction angles was observed in the X-ray diffraction patterns of doped specimens. Microstructure of all gypsum specimens consisted of many rod-like small crystals entangled to each other with more elongation and higher thickness in the case of gypsum:Sr. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one. |
| Databáze: | OpenAIRE |
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