Sleep Apnea and 20-Year Follow-Up for All-Cause Mortality, Stroke, and Cancer Incidence and Mortality in the Busselton Health Study Cohort
| Autor: | Nathaniel S. Marshall, Keith Wong, Ronald R. Grunstein, Stewart R J Cullen, Matthew Knuiman |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pediatrics medicine.medical_specialty genetic structures Coronary Disease Kaplan-Meier Estimate Disease Severity of Illness Index Coronary artery disease Risk Factors Neoplasms Severity of illness medicine Humans cardiovascular diseases Stroke Aged Sleep Apnea Obstructive business.industry Incidence Incidence (epidemiology) Sleep apnea Western Australia Middle Aged New Research medicine.disease respiratory tract diseases Obstructive sleep apnea Neurology Cardiovascular Diseases Cohort Commentary Physical therapy Neurology (clinical) business Follow-Up Studies |
| Zdroj: | J Clin Sleep Med |
| ISSN: | 1550-9397 1550-9389 |
| DOI: | 10.5664/jcsm.3600 |
| Popis: | To ascertain whether objectively measured obstructive sleep apnea (OSA) independently increases the risk of all cause death, cardiovascular disease (CVD), coronary heart disease (CHD), stroke or cancer.Community-based cohort.400 residents of the Western Australian town of Busselton.OSA severity was quantified via the respiratory disturbance index (RDI) as measured by a single night recording in November-December 1990 using the MESAM IV device, along with a range of other risk factors. Follow-up for deaths and hospitalizations was ascertained via record linkage to the end of 2010.We had follow-up data in 397 people and then removed those with a previous stroke (n = 4) from the mortality/ CVD/CHD/stroke analyses and those with cancer history from the cancer analyses (n = 7). There were 77 deaths, 103 cardiovascular events (31 strokes, 59 CHD) and 125 incident cases of cancer (39 cancer fatalities) during 20 years follow-up. In fully adjusted models, moderate-severe OSA was significantly associated with all-cause mortality (HR = 4.2; 95% CI 1.9, 9.2), cancer mortality (3.4; 1.1, 10.2), incident cancer (2.5; 1.2, 5.0), and stroke (3.7; 1.2, 11.8), but not significantly with CVD (1.9; 0.75, 4.6) or CHD incidence (1.1; 0.24, 4.6). Mild sleep apnea was associated with a halving in mortality (0.5; 0.27, 0.99), but no other outcome, after control for leading risk factors.Moderate-to-severe sleep apnea is independently associated with a large increased risk of all-cause mortality, incident stroke, and cancer incidence and mortality in this community-based sample. |
| Databáze: | OpenAIRE |
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