Location of preganglionic neurons is independent of birthdate but is correlated to reelin-producing cells in the spinal cord
| Autor: | Yee Ping Yip, Guangdou Zhou, Joseph W. Yip, Christine Capriotti |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Sympathetic Nervous System
Autonomic Fibers Preganglionic Cell Adhesion Molecules Neuronal Period (gene) Gestational Age Nerve Tissue Proteins Mice Neurologic Mutants Reeler Cell Movement Interneurons medicine Animals Reelin Extracellular Matrix Proteins biology General Neuroscience Serine Endopeptidases Neurogenesis Abnormal positions Embryo Mammalian Spinal cord Reelin Protein medicine.anatomical_structure Spinal Cord nervous system biology.protein Neuron Past study Neuroscience |
| Zdroj: | The Journal of Comparative Neurology. 475:564-574 |
| ISSN: | 1096-9861 0021-9967 |
| DOI: | 10.1002/cne.20212 |
| Popis: | Many studies suggest that during neuronal development the birthdate of a neuron appears to have significant consequences for its ultimate location and identity. Our past study shows that sympathetic preganglionic neurons (SPN) in mice lacking the reelin gene settle in abnormal positions in the spinal cord. In the present study we determined that birthdate is not a factor contributing to the abnormal position of SPN in reeler. In both normal and reeler mice the period of neurogenesis of SPN was similar, and the final location of SPN in the spinal cord was independent of birthdate. Additionally, we have identified at least two types of ventral interneurons, V1 and V2, that are involved in the production of Reelin and the positioning of SPN in the spinal cord. J. Comp. Neurol. 475:564–574, 2004. © 2004 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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