Cerebrospinal fluid ferritin levels, a sensitive diagnostic test in delayed presenting subarachnoid haemorrhage
Autor: | Neil Kitchen, Mary E. Kerr, Ian Appleby, Martin D. Smith, Axel Petzold, Viki Worthington |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Adult
Male Spinal tap Subarachnoid hemorrhage Time Factors Bilirubin Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Spinal Puncture Article chemistry.chemical_compound Young Adult Cerebrospinal fluid Predictive Value of Tests medicine Humans cardiovascular diseases Prospective Studies Prospective cohort study Aged biology business.industry Rehabilitation Middle Aged Subarachnoid Hemorrhage medicine.disease film.actor nervous system diseases Up-Regulation Ferritin chemistry film Anesthesia Predictive value of tests Case-Control Studies Ferritins biology.protein Linear Models Surgery Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed Biomarkers |
Popis: | The workup of patients with suspected subarachnoid hemorrhage (SAH) presenting late is complicated by a loss of diagnostic sensitivity of computed tomography (CT) brain imaging and cerebrospinal fluid (CSF) bilirubin levels. In this prospective longitudinal study of CSF ferritin levels in SAH, serial CSF samples from 14 patients with aneurysmal SAH requiring extraventricular drainage (EVD) were collected. The control group comprised 44 patients presenting with headache suspicious of SAH. Nine patients underwent a traumatic spinal tap. CSF ferritin levels were significantly higher in the patients with SAH compared with controls (P.0001). The upper reference range of CSF ferritin is 12 ng/mL, and there was no significant difference between the traumatic and normal spinal taps (mean, 9.0 ng/mL vs 3.9 ng/mL; P = .59). CSF ferritin levels increased after SAH, from an average of 65 ng/mL on day 1 to 1750 ng/mL on day 11 (P.01). Both the Fisher and Columbia CT scores were significantly correlated with CSF ferritin level. The increase in CSF ferritin level after SAH and possibly may provide additional diagnostic information in patients with suspected SAH who present late to the clinic. |
Databáze: | OpenAIRE |
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