Advanced electrocardiographic predictors of mortality in familial dysautonomia
| Autor: | H. Marthol, Vito Starc, Marcin Tutaj, Max J. Hilz, Susanne Buechner, Alan H. Feiveson, Felicia B. Axelrod, I. Solaimanzadeh, E. C. Greco, Jude L. DePalma, T. T. Schlegel |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Bradycardia medicine.medical_specialty Adolescent Heart disease Heart Ventricles QT interval Electrocardiography Cellular and Molecular Neuroscience Heart Rate Predictive Value of Tests Internal medicine Heart rate Dysautonomia Familial medicine Humans Heart rate variability cardiovascular diseases Mortality Hypoxia Endocrine and Autonomic Systems business.industry Sleep apnea Arrhythmias Cardiac Middle Aged medicine.disease Signal-averaged electrocardiogram Surgery Death Sudden Cardiac Familial dysautonomia Cardiology Female Hypertrophy Left Ventricular Neurology (clinical) medicine.symptom Respiratory Insufficiency business Biomarkers |
| Zdroj: | Autonomic Neuroscience. 144:76-82 |
| ISSN: | 1566-0702 |
| DOI: | 10.1016/j.autneu.2008.08.016 |
| Popis: | Objective To identify electrocardiographic predictors of mortality in patients with familial dysautonomia (FD). Methods Ten-minute resting high-fidelity 12-lead electrocardiograms (ECGs) were obtained from 14 FD patients and 14 age/gender-matched healthy subjects. Multiple conventional and advanced ECG parameters were studied for their ability to predict mortality over a subsequent 4.5-year period, including representative parameters of heart rate variability (HRV), QT variability (QTV), T-wave complexity, signal averaged ECG, and 3-dimensional ECG. Results Four of the 14 FD patients died during the follow-up period, three with concomitant pulmonary disorder. Of the ECG parameters studied, increased non-HRV-correlated QTV and decreased HRV were the most predictive of death. Compared to controls as a group, FD patients also had significantly increased ECG voltages, JTc intervals and waveform complexity, suggestive of structural heart disease. Conclusion Increased QTV and decreased HRV are markers for increased risk of death in FD patients. When present, both markers may reflect concurrent pathological processes, especially hypoxia due to pulmonary disorders and sleep apnea. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect