Toward the Total Synthesis of Alpkinidine: Michael Addition to Isoquinolinetrione CE Ring-System Synthons
| Autor: | Marco Buccini, Francis Dhoro, Louisa Tham, Brian W. Skelton, Craig M. Williams, Matthew J. Piggott |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | ACS omega. 7(23) |
| ISSN: | 2470-1343 |
| Popis: | Strategies toward the total synthesis of the marine pyrroloacridine alkaloid alpkinidine have been explored, focusing on linking quinonoid CE ring-system synthons with the A ring, followed by condensation to form the B and D rings. The key Michael addition of the ester enolate derived from ethyl |
| Databáze: | OpenAIRE |
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