Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary - an experience in Taiwan

Autor: I-How Chen, Chung-Jan Kang, Kang-Hsing Fang, Eric Yuan-Chao Chen, Chun-Ta Liao, Morgan Fu-Ti Chang, Shiang-Fu Huang, Hung-Ming Wang, Joseph Tung-Chieh Chang, Chieh-Yu Lin
Jazyk: angličtina
Předmět:
Adult
Male
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty
Adolescent
lcsh:R895-920
medicine.medical_treatment
Leucovorin
Taiwan
Kaplan-Meier Estimate
lcsh:RC254-282
Young Adult
Hypopharyngeal Neoplasm
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Radiology
Nuclear Medicine and imaging
Radical surgery
Stage (cooking)
Prospective cohort study
Digestive System Surgical Procedures
Aged
Neoplasm Staging
Tegafur
Aged
80 and over
Hypopharyngeal Neoplasms
Radiotherapy
business.industry
Incidence
Research
Induction chemotherapy
Neoplasms
Second Primary
Hypopharyngeal cancer
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Combined Modality Therapy
Surgery
Radiation therapy
Oncology
Radiology Nuclear Medicine and imaging
Concomitant
Female
Cisplatin
business
Zdroj: Radiation Oncology, Vol 5, Iss 1, p 91 (2010)
Radiation Oncology (London, England)
ISSN: 1748-717X
DOI: 10.1186/1748-717x-5-91
Popis: Purpose The aim of this study was to evaluate treatment results in our hypopharyngeal cancer patients. Patients and Methods A total of three hundred and ninety five hypopharyngeal cancer patients received radical treatment at our hospital; 96% were male. The majority were habitual smokers (88%), alcohol drinkers (73%) and/or betel quid chewers (51%). All patients received a CT scan or MRI for tumor staging before treatment. The stage distribution was stage I: 2 (0.5%); stage II: 22 (5.6%); stage III: 57 (14.4%) and stage IV: 314 (79.5%). Radical surgery was used first in 81 patients (20.5%), and the remaining patients (79.5%) received organ preservation-intended treatment (OPIT). In the OPIT group, 46 patients received radiotherapy alone, 156 patients received chemotherapy followed by radiotherapy (CT/RT) and 112 patients received concomitant chemo-radiotherapy (CCRT). Results The five-year overall survival rates for stages I/II, III and IV were 49.5%, 47.4% and 18.6%, respectively. There was no significant difference in overall and disease-specific survival rates between patients who received radical surgery first and those who received OPIT. In the OPIT group, CCRT tended to preserve the larynx better (p = 0.088), with three-year larynx preservation rates of 44.8% for CCRT and 27.2% for CT/RT. Thirty-seven patients developed a second malignancy, with an annual incidence of 4.6%. Conclusions There was no survival difference between OPIT and radical surgery in hypopharyngeal cancer patients at our hospital. CCRT may offer better laryngeal preservation than RT alone or CT/RT. However, prospective studies are still needed to confirm this finding. Additionally, second primary cancers are another important issue for hypopharyngeal cancer management.
Databáze: OpenAIRE
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