Patient-initiated, pressure-regulated, volume-controlled ventilation compared with intermittent mandatory ventilation in neonates: a prospective, randomised study
| Autor: | P. Kawczyński, A. Piotrowski, W. Sobala |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Artificial ventilation Time Factors medicine.medical_treatment Critical Care and Intensive Care Medicine Statistics Nonparametric law.invention Positive-Pressure Respiration law Intensive care medicine Humans Mechanical ventilation Respiratory Distress Syndrome Newborn Intermittent mandatory ventilation Respiratory distress business.industry Infant Newborn Pneumonia Infant Low Birth Weight Intensive care unit Logistic Models Respiratory failure Anesthesia Multivariate Analysis Intensive Care Neonatal Breathing Female Poland business |
| Zdroj: | Intensive Care Medicine. 23:975-981 |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s001340050441 |
| Popis: | To compare the effects of patient-initiated, pressure-regulated, volume-controlled ventilation (PRVC) with pressure-preset intermittent mandatory ventilation (IMV) in neonates with respiratory failure.Randomised, prospective study.Intensive care unit (14 beds) in a 300-bed paediatric teaching hospital.60 neonates with respiratory distress syndrome (RDS) or congenital pneumonia, weighing2500 g and requiring mechanical ventilation.Ventilatory support until extubation via either IMV (n = 30) or PRVC (n = 27). In PRVC, the tidal volume (VT) was preset and pressure-controlled breaths delivered with peak inspiratory pressure values adapted to achieve the preset VT.Main outcome measures were duration of ventilation and incidence of bronchopulmonary dysplasia (BPD). Pulmonary air leaks and intraventricular haemorrhage (IVH) were considered major adverse effects. Demographic data, ventilation parameters and arterial/alveolar oxygen tension ratio were similar at randomisation. Duration of ventilation and incidence of BPD were not decreased by the use of PRVC. Air leaks occurred in 3 neonates in the PRVC group and in 7 babies treated with IMV (NS). The incidence of IVH gradeII was lower in babies treated with PRVC (p0.05). In a subgroup of neonates weighing1000 g, the duration of ventilation and incidence of hypotension were reduced in the PRVC group (p0.05).Patient-initiated, pressure-regulated, volume-controlled ventilation can be safely used in neonates and may contribute to a lower incidence of complications. |
| Databáze: | OpenAIRE |
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