The microscopical characterization of membranes poly (l-glycolic-co-lactic acid) with and without added plasticizer: an in vivo study
| Autor: | Luciana Pietro, D. R. M. Silva, Maria do Carmo Alberto-Rincon, Eliana Aparecida de Rezende Duek |
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| Rok vydání: | 2007 |
| Předmět: |
Materials science
Biomedical Engineering Biophysics Bioengineering Biomaterials chemistry.chemical_compound Polymer degradation Microscopy Electron Transmission Polylactic Acid-Polyglycolic Acid Copolymer Plasticizers In vivo Absorbable Implants Materials Testing Copolymer Animals Organic chemistry Lactic Acid Rats Wistar Skin Plasticizer Membranes Artificial Rats Lactic acid PLGA Membrane Neutrophil Infiltration Chemical engineering chemistry Degradation (geology) Female Microscopy Polarization Polyglycolic Acid |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 19:1069-1074 |
| ISSN: | 1573-4838 0957-4530 |
| Popis: | The development of biodegradable materials has lead to renewed interest in the study of their interactions with the host organism in order to make the resulting products appropriate for use as temporary materials in clinical research, as well as important therapeutic applications. The copolymer poly (L-lactic-co-glycolic acid) or PLGA membranes have been used for several purposes. The physical properties of these materials can be modified by the addition of a plasticizer, such as the triethylcitrate, to provide flexibility and porosity to the implants, and enhance control of the polymer degradation time. Membranes with 7% plasticizer and without plasticizer (triethylcitrate) were compared. Membranes without plasticizer were denser and more compact than those with plasticizer. Two days and 30 days after implantation, the membranes with and without plasticizer showed little degradation. Sixty days and 120 days after implantation, the membranes with 7% plasticizer showed more cell invasion, and tissue adherence, as well as rapid degradation when compared to membranes without plasticizer. |
| Databáze: | OpenAIRE |
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