Effect of Psychological Stress on [35S]TBPS Binding in Rat Brain
| Autor: | Tiziana Mennini, M. Cinquanta, M C Foddi |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Clinical Biochemistry Central nervous system Convulsants Toxicology Biochemistry Rats Sprague-Dawley Synapse Behavioral Neuroscience Stress Physiological Internal medicine medicine Animals Binding site Biological Psychiatry Pharmacology Binding Sites Chemistry Ipsapirone Brain Bridged Bicyclo Compounds Heterocyclic Ligand (biochemistry) Rats medicine.anatomical_structure Endocrinology Cerebral cortex GABAergic Diazepam medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 58:373-377 |
| ISSN: | 0091-3057 |
| Popis: | This study was designed to determine whether psychological stress alters the function of the GABAergic synapse, examined as biochemical changes of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding, in unwashed membranes of rat cerebral cortex. Psychological stress increased the number of [35S]TBPS binding sites by 22%. This enhancement was very similar to that after acute foot shock (24%). Psychological stress was induced very rapidly, because only 1 day after previous foot shock exposure, [35S]TBPS binding was increased by 23%. Diazepam [3 mg/kg intraperitoneally (subcutaneously)] and ipsapirone (5 mg/kg subcutaneously), injected 30 min before psychological stress, antagonized the enhancement of [35S]TBPS binding. This result suggests that psychological stress is a good animal model for investigating the various biochemical changes related to stress, avoiding the physical components associated with most of the normally used stressors and mimicking only emotional state alterations. |
| Databáze: | OpenAIRE |
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