The influence of intracerebral streptozotocin and/or cadmium on memory processes in mice exposed to transient cerebral oligemia
| Autor: | Maria Klatka, Andrzej Borzecki, Katarzyna Sygit, Katarzyna Wójtowicz-Chomicz, Małgorzata Kowal, Anna Pikuła, Monika Sałaga-Pylak |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis Central nervous system Hypovolemia Carbohydrate metabolism Cadmium chloride Toxicology Spatial memory Streptozocin Brain ischemia chemistry.chemical_compound Mice Memory Internal medicine Occlusion Medicine Animals biology Behavior Animal business.industry Brain Streptozotocin medicine.disease Insulin receptor medicine.anatomical_structure Endocrinology chemistry Ischemic Attack Transient Anesthesia biology.protein Exploratory Behavior Female business medicine.drug Cadmium |
| Zdroj: | Journal of toxicology and environmental health. Part A. 73(17-18) |
| ISSN: | 1528-7394 |
| Popis: | The aim of the study was to examine the effects of simultaneous acute exposure to cadmium (Cd) and in the presence of streptozotozin (STZ) on the central nervous system (CNS) memory processes in mice subjected to transient brain ischemia. In order to obtain transient brain ischemia, operative occlusion of common carotid arteries for 30 min was performed. Cadmium chloride was administered intraperitoneally (ip) after the surgery at a single dose of 0.1 LD(50) (LD(50) = 14 mg/kg). Disturbances in glucose metabolism in the brain tissue were induced by bilateral intracerebral administration of STZ, a drug that inhibits the function of a neuronal insulin receptor. Long-term memory was evaluated by means of a step-through passive avoidance task. Spatial working memory expressed as spontaneous alternations was tested in the Y-maze test. Coexposure to brain oligemia and STZ on the CNS produced significant impairment of long-term memory processes in mice. An additional exposure to Cd exacerbated the deficits of these processes. These results indicate that brain oligemia, Cd, and altered glucose metabolism may aggravate adverse effects on memory. |
| Databáze: | OpenAIRE |
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