Health-related quality of life among children with transfusion-dependent thalassemia: A cross-sectional study in Malaysia
| Autor: | Noor Syahireen Mohammed, Jacqueline Hui Yi Wong, Hishamshah Mohd Ibrahim, Asrul Akmal Shafie, Hamidah Alias, Irwinder Kaur Chhabra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Parents medicine.medical_specialty QoL thalassemia cross-sectional Adolescent Cross-sectional study Health-related quality of life Thalassemia Transfusion-dependent thalassemia lcsh:Computer applications to medicine. Medical informatics Correlation 03 medical and health sciences 0302 clinical medicine Quality of life children Internal medicine Humans Medicine Transfusion dependent thalassemia 030212 general & internal medicine Child transfusion Health related quality of life business.industry Research Public Health Environmental and Occupational Health Malaysia Regression analysis health General Medicine medicine.disease Cross-Sectional Studies quality of life Child Preschool 030220 oncology & carcinogenesis lcsh:R858-859.7 PedsQL™ 4.0 Female Self Report business Psychosocial |
| Zdroj: | Health and Quality of Life Outcomes Health and Quality of Life Outcomes, Vol 18, Iss 1, Pp 1-11 (2020) |
| Popis: | Background The treatment of children with transfusion-dependent thalassemia (TDT) in Malaysia has progressed since 2005. This study provides an updated health-related quality of life (HRQoL) assessment for children with the disorder and the factors affecting the HRQoL. MethodsA cross-sectional HRQoL survey of Malaysian children with TDT was conducted using the PedsQL™ 4.0 Generic Core Scales. Patients with non-transfusion dependent thalassemia and other haemoglobinopathies were excluded. Parent-proxy and self-reported HRQoL scores were obtained using a multi-stage convenient sampling. The relationship between HRQoL scores and demographic factors were tested using association, correlation and regression analysis. Results A total of 368 patients were recruited. The mean (SD) Total Summary Score (TSS) was 80.12(13.87). Predictors for a lower TSS was an increasing age group and the use of dual chelating agents (R2 = 0.057, F (4, 359) = 5.40, p = 2 = 0.075, F (5,358) = 5.80, p = 2 = 0.041, F (1, 362) = 15.60, p = ConclusionThe HRQoL of TDT children in Malaysia has improved over the last decade owing to the better access in treatment. However, further effort is needed to improve the school functioning dimension. |
| Databáze: | OpenAIRE |
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