Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study
| Autor: | Jeanette J. McCarthy, John R. Guyton, Kaela Pearce, Jennifer Rowell, Lillian F. Lien, Sunil Suchindran, Ashlee M. Benjamin |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Genetics
0303 health sciences lcsh:Internal medicine Framingham Risk Score Article Subject business.industry Offspring Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Locus (genetics) medicine.disease Bioinformatics Obesity 03 medical and health sciences 0302 clinical medicine Framingham Heart Study Genotype Cohort Genetic variation Medicine business lcsh:RC31-1245 030304 developmental biology Research Article |
| Zdroj: | Journal of Obesity, Vol 2011 (2011) Journal of Obesity |
| ISSN: | 2090-0708 |
| DOI: | 10.1155/2011/329038 |
| Popis: | Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream ofLYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at theLYPLAL1locus and obesity-related traits. |
| Databáze: | OpenAIRE |
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