Early Outcomes of Heart Transplantation Using Donation After Circulatory Death Donors in the United States
| Autor: | Jennie H. Kwon, Alexander D. Ghannam, Khaled Shorbaji, Brett Welch, Z.A. Hashmi, Ryan J. Tedford, Arman Kilic |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Circulation: Heart Failure. 15 |
| ISSN: | 1941-3297 1941-3289 |
| Popis: | Background: Limited donor availability and evolution in procurement techniques have renewed interest in heart transplantation (HT) with donation after circulatory death (DCD). The aim of this study is to evaluate outcomes of HT using DCD in the United States. Methods: The United Network for Organ Sharing registry was used to identify adult HT recipients from 2019 to 2021. Recipients were stratified between DCD and donation after brain death. Propensity-score matching was performed. Cox proportional hazards was used to identify independent predictors of 1-year mortality. Kaplan-Meier analysis was used to estimate 1-year survival. Results: Of 7496 HTs, 229 DCD and 7267 donation after brain death recipients were analyzed. The frequency of DCD HT increased from 0.2% of all HT in 2019 to 6.4% in 2021 ( P P P =0.44). Among DCD HTs, increasing recipient age and waitlist time predicted 1-year mortality on univariable analysis. Conclusions: Rates of DCD HT in the United States are increasing. This practice appears safe and feasible as mortality outcomes are comparable to donation after brain death. Although this study represents early adopting centers, outcomes of the experience for DCD HT in the United States is consistent with existing international data and encourages broader utilization of this practice. |
| Databáze: | OpenAIRE |
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