Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons
| Autor: | Keith W. Kelley, Katherine McCrea, Rodney W. Johnson, Robert Dantzer, Robert H. McCusker, Samantha M. Zunich, Suzanne R. Broussard |
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| Rok vydání: | 2006 |
| Předmět: |
Intracellular Fluid
MAPK/ERK pathway medicine.medical_specialty medicine.medical_treatment Blotting Western Immunology Glutamic Acid Tropomyosin receptor kinase B Mice Insulin-like growth factor Neurotrophic factors Internal medicine medicine Animals Receptor trkB Immunology and Allergy Insulin-Like Growth Factor I Phosphorylation Extracellular Signal-Regulated MAP Kinases Cerebral Cortex Neurons Brain-derived neurotrophic factor Mice Inbred BALB C biology Chemistry Brain-Derived Neurotrophic Factor Growth factor Glutamate receptor Endocrinology nervous system Neurology biology.protein Calcium Neurology (clinical) Neurotrophin |
| Zdroj: | Journal of Neuroimmunology. 179:186-190 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2006.06.014 |
| Popis: | Insulin-like growth factor (IGF)-I and brain-derived neurotrophic factor (BDNF) act within the brain to enhance neuronal survival and plasticity. We extend these findings by showing that the presence of both neurotrophins is required to depress the rise in intracellular Ca2+ caused by glutamate in primary cultures of cerebrocortical neurons. IGF-I enhanced expression of BDNF receptors (Trk-B) and increased the ability of BDNF to induce ERK1/2 phosphorylation. This IGF-I-induced increase in BDNF responsiveness describes a new interaction between these peptides in the brain. |
| Databáze: | OpenAIRE |
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