Meroterpenoids with a large conjugated system from Ganoderma lucidum and their inhibitory activities against renal fibrosis

Autor:	Yong-Xiang Wang, Yun-Li Peng, Bin Qiu, Qing Lv, Li-Shu-Xin Huang, Yong-Xian Cheng
Rok vydání:	2022
Předmět:	Pharmacology Transforming Growth Factor beta1 Reishi Molecular Structure Terpenes Drug Discovery Animals Ganoderma General Medicine Fibrosis Rats
Zdroj:	Fitoterapia. 161
ISSN:	1873-6971
Popis:	Baoslingzhines A-E (1-5), five new meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. The structures including their absolute configurations were characterized by using spectroscopic and computational methods. Compound 1 is a novel trinormeroterpenoid featuring the presence of an unusual dihydronaphthalene representing an unprecedented meroterpenoid skeleton. Compounds 2-4 are mononormeroterpenoids characteristic of a large conjugated system. Among them, racemic 3 and 4 were separated by HPLC on chiral phase. Biological evaluation toward kidney fibrosis found that compounds 2 and (+)-3 could inhibit the expression of fibronectin and collagen I dose dependently in TGF-β1-induced rat kidney proximal tubular cells (NRK-52e). Additionally, (+)-3 could also down regulate ɑ-SMA in a concentration dependent manner. Further investigation showed that 2 could inhibit Smad2 phosphorylation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2c35882c3eda3e582511d843705639 https://pubmed.ncbi.nlm.nih.gov/35914706 Zobrazit plný text záznamu Full Text from ScienceDirect