Hippocampal volume in women victimized by childhood sexual abuse
Autor: | Murray B. Stein, B. McClarty, Catherine Koverola, M. G. Torchia, Cindy Hanna |
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Rok vydání: | 1997 |
Předmět: |
Adult
Child abuse medicine.medical_specialty Alcohol Drinking Neurotic Disorders Poison control Dissociative Disorders Hippocampal formation Hippocampus Severity of Illness Index Temporal lobe Stress Disorders Post-Traumatic Severity of illness medicine Humans Child Psychiatry Applied Psychology Analysis of Variance Child Abuse Sexual medicine.disease Psychiatry and Mental health Cross-Sectional Studies Sexual abuse Case-Control Studies Brain size Female Psychology Psychological trauma Clinical psychology |
Zdroj: | Psychological Medicine. 27:951-959 |
ISSN: | 0033-2917 |
Popis: | Background. Several prior studies have found reduced hippocampal volume in victims of psychological trauma with post-traumatic stress disorder (PTSD). We were interested to determine if this finding was evident in women who were victimized by severe sexual abuse in childhood. Methods. In this study, hippocampal volume was measured using quantitative magnetic resonance imaging (MRI) in 21 women who reported being severely sexually abused in childhood and 21 sociodemographically similar women without abuse histories. Results. Women who reported sexual victimization in childhood had significantly reduced (5% smaller) left-sided hippocampal volume compared to the non-victimized women. Hippocampal volume was also smaller on the right side, but this failed to reach statistical significance. Left-sided hippocampal volume correlated highly (r s flfi0‐73) with dissociative symptom severity, but not with indices of explicit memory functioning. Conclusions. These findings, which are generally consistent with prior reports of reduced hippocampal volume in combat veterans with PTSD, suggest that diminished hippocampal size may be either a consequence of trauma exposure or a risk factor for the development of psychiatric complications following trauma exposure. The observed relationship between symptom severity and hippocampal volume suggests that mesial temporal lobe dysfunction may directly mediate certain aspects of PTSD and dissociative disorder symptomatology. |
Databáze: | OpenAIRE |
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