Effect of royal jelly ingestion for six months on healthy volunteers
Autor: | Takahide Ikeda, Tatsuo Ishizuka, Hideyuki Okada, Ichiro Mori, Yoshihiro Uno, Kazuo Kajita, Hiroyuki Morita, Kei Fujioka |
---|---|
Rok vydání: | 2012 |
Předmět: |
Male
Time Factors Medicine (miscellaneous) Hematocrit Gastroenterology Dehydroepiandrosterone sulfate chemistry.chemical_compound Japan Royal jelly Ingestion Testosterone Erythropoiesis lcsh:RC620-627 Aged 80 and over Nutrition and Dietetics medicine.diagnostic_test Fatty Acids Glucose tolerance Middle Aged Intention to Treat Analysis lcsh:Nutritional diseases. Deficiency diseases Mental Health Female lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty food.ingredient SF-36 lcsh:TX341-641 Placebo Insulin resistance food Double-Blind Method Internal medicine medicine Humans Aged Psychiatric Status Rating Scales Intention-to-treat analysis business.industry Research Androstenedione medicine.disease Endocrinology chemistry Dietary Supplements Hematinics Insulin Resistance business |
Zdroj: | Nutrition Journal, Vol 11, Iss 1, p 77 (2012) Nutrition Journal |
ISSN: | 1475-2891 |
Popis: | Background Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans. Methods We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention. Results Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x106 /μL for the RJ group vs. -0.01x106 /μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276). Conclusions Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects. |
Databáze: | OpenAIRE |
Externí odkaz: |