Effect of royal jelly ingestion for six months on healthy volunteers

Autor: Takahide Ikeda, Tatsuo Ishizuka, Hideyuki Okada, Ichiro Mori, Yoshihiro Uno, Kazuo Kajita, Hiroyuki Morita, Kei Fujioka
Rok vydání: 2012
Předmět:
Male
Time Factors
Medicine (miscellaneous)
Hematocrit
Gastroenterology
Dehydroepiandrosterone sulfate
chemistry.chemical_compound
Japan
Royal jelly
Ingestion
Testosterone
Erythropoiesis
lcsh:RC620-627
Aged
80 and over
Nutrition and Dietetics
medicine.diagnostic_test
Fatty Acids
Glucose tolerance
Middle Aged
Intention to Treat Analysis
lcsh:Nutritional diseases. Deficiency diseases
Mental Health
Female
lcsh:Nutrition. Foods and food supply
Adult
medicine.medical_specialty
food.ingredient
SF-36
lcsh:TX341-641
Placebo
Insulin resistance
food
Double-Blind Method
Internal medicine
medicine
Humans
Aged
Psychiatric Status Rating Scales
Intention-to-treat analysis
business.industry
Research
Androstenedione
medicine.disease
Endocrinology
chemistry
Dietary Supplements
Hematinics
Insulin Resistance
business
Zdroj: Nutrition Journal, Vol 11, Iss 1, p 77 (2012)
Nutrition Journal
ISSN: 1475-2891
Popis: Background Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans. Methods We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention. Results Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x106 /μL for the RJ group vs. -0.01x106 /μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276). Conclusions Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.
Databáze: OpenAIRE
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